TTD | Drug: D01CRJ

Drug General Information
Drug ID	D01CRJ
Former ID	DIB021259
Drug Name	ZK-158252
Synonyms	ZK158252; ZK 158252
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541352]
Structure		Download 2D MOL
Formula	C29H36O3
InChI	InChI=1S/C29H36O3/c30-27(29(22-11-23-29)21-10-14-24-12-2-1-3-13-24)19-8-6-17-25-15-4-5-16-26(25)18-7-9-20-28(31)32/h1-3,6,8,12-13,17-19,25,27,30H,4-5,7,9,11,15-16,20-23H2,(H,31,32)/b17-6+,19-8+,26-18+
InChIKey	HILRZHRCCODTSA-AHQVELJISA-N
PubChem Compound ID	9824142
PubChem Substance ID	14783242, 44860096, 80822850, 85223316, 178102783
Target and Pathway
Target(s)	Leukotriene B4 receptor 2	Target Info	Antagonist	[526017]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 541352	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6162).
Ref 526017	Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. Epub 2001 Jan 18.

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Drug Information