Drug General Information
Drug ID	D01DFX
Former ID	DNC014518
Drug Name	4-[(2-Methyl-1H-imidazol-1-yl)methyl]pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531201]
Structure		Download 2D MOL 3D MOL
Formula	C10H11N3
Canonical SMILES	CC1=NC=CN1CC2=CC=NC=C2
InChI	1S/C10H11N3/c1-9-12-6-7-13(9)8-10-2-4-11-5-3-10/h2-7H,8H2,1H3
InChIKey	MNSNMTASPOHKEI-UHFFFAOYSA-N
PubChem Compound ID	52949342
Target and Pathway
Target(s)	Nitric-oxide synthase, brain	Target Info	Inhibitor	[531201]
	Nitric oxide synthase, inducible	Target Info	Inhibitor	[531201]
BioCyc Pathway	Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	Phagosome
	Circadian entrainment
	Long-term depression
	Salivary secretion
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
	HIF-1 signaling pathway
	Peroxisome
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Pathways in cancer
	Small cell lung cancer
NetPath Pathway	EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	IL2 Signaling Pathway
PANTHER Pathway	CCKR signaling map ST
Pathway Interaction Database	IL12-mediated signaling events
	Alpha9 beta1 integrin signaling events
	ATF-2 transcription factor network
	IL23-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	HIF-1-alpha transcription factor network
PathWhiz Pathway	Arginine and Proline Metabolism
Reactome	ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
	Nitric oxide stimulates guanylate cyclase
WikiPathways	Monoamine Transport
	Myometrial Relaxation and Contraction Pathways
	Amyotrophic lateral sclerosis (ALS)
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Alzheimers Disease
	Effects of Nitric Oxide
	Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
	AGE/RAGE pathway
References
Ref 531201	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Ref 531201	Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.