Drug Information
Drug General Information | |||||
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Drug ID |
D01ESB
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Former ID |
DPR000162
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Drug Name |
YM-992
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Synonyms |
Lubazodone HCl; Lubazodone hydrochloride; Lubazodone hydrochloride [USAN]; YM992; Lubazodone (TN); Lubazodone hydrochloride (USAN); SM-50C; YM-35992; (2S)-2-[(7-fluoro-2,3-dihydro-1H-inden-4-yl)oxymethyl]morpholine hydrochloride; (S)-2-(((7-fluoro-4-indanyl)oxy)methyl)morpholine hydrochloride
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Drug Type |
Small molecular drug
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Indication | Depression [ICD9: 311; ICD10:F30-F39] | Discontinued in Phase 2 | [1] | ||
Therapeutic Class |
Psychiatric
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Company |
Yamanouchi
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Structure |
Download2D MOL |
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Formula |
C14H19ClFNO2
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Canonical SMILES |
C1CC2=C(C=CC(=C2C1)F)OCC3CNCCO3.Cl
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InChI |
1S/C14H18FNO2.ClH/c15-13-4-5-14(12-3-1-2-11(12)13)18-9-10-8-16-6-7-17-10;/h4-5,10,16H,1-3,6-9H2;1H/t10-;/m0./s1
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InChIKey |
HWEMEKZYQCJVEZ-PPHPATTJSA-N
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CAS Number |
CAS 161178-07-0
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [2] | |
Sodium-dependent serotonin transporter | Target Info | Inhibitor | [2] | ||
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channelshsa04726:Serotonergic synapse | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | 5HT2 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway | ||||
5HT2 type receptor mediated signaling pathway | |||||
5HT3 type receptor mediated signaling pathway | |||||
5HT4 type receptor mediated signaling pathway | |||||
Reactome | Serotonin receptors | ||||
G alpha (q) signalling events | |||||
WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, OtherWP727:Monoamine Transport | |||||
NRF2 pathway | |||||
Synaptic Vesicle Pathway | |||||
Serotonin Transporter Activity | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008166) | ||||
REF 2 | Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. | ||||
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