Drug Information

Drug General Information
Drug ID
D01ESJ
Former ID
DIB004390
Drug Name
Luzindole
Synonyms
Luzindole, Interneuron
Drug Type
Small molecular drug
Indication Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] Terminated [538841], [544715]
Company
Endo Pharmaceuticals Solutions Inc
Structure
Download
2D MOL

3D MOL
Formula
C19H20N2O
InChI
InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
InChIKey
WVVXBPKOIZGVNS-UHFFFAOYSA-N
CAS Number
CAS 117946-91-5
PubChem Compound ID
122162
PubChem Substance ID
3153206, 6053777, 10239970, 11113752, 12016180, 14849231, 24896315, 26751931, 29302606, 48029730, 48329130, 50172621, 57339994, 85087357, 85209152, 85787573, 91614231, 103206857, 104415192, 118508042, 126434999, 126591041, 126679033, 129641780, 134223704, 135077966, 135650539, 135697535, 136351165, 137000735, 137242492, 143552894, 162022694, 162092655, 163121981, 164811890, 179149659, 184594679, 204369949, 223454621, 223655888, 230755032, 241181946, 241377507, 249816488, 252160070, 252272687, 252501323
Target and Pathway
Target(s) Melatonin receptor Target Info Modulator [533364]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538841(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1363).
Ref 544715Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000705)
Ref 533364Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther. 1988 Sep;246(3):902-10.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.