Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01FLR
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| Former ID |
DIB008071
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| Drug Name |
Vanilloid VR1 receptor antagonists
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| Synonyms |
Vanilloid VR1 receptor antagonists (urinary incontinence); Vanilloid VR1 receptor antagonists (urinary incontinence), Bayer
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| Indication | Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] | Investigative | [1] | ||
| Company |
Bayer Yakuhin Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(C(F)(F)F)c(ccc(NC(=O)Nc2c3c(c(cc2Cl)Cl)ccc(c3)O)c1)C<br />l
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| Target and Pathway | |||||
| Target(s) | Vanilloid receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | WO patent application no. 2000050387A1, Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). | ||||
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