Drug General Information
Drug ID	D01HLO
Former ID	DIB013478
Drug Name	PF-05190457
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 1	[523786]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Growth hormone secretagogue receptor type 1	Target Info	Modulator	[551215]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	Leptin Signaling Pathway
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523786	ClinicalTrials.gov (NCT01522807) A Study Of Three PF-05190457 Formulations In Healthy Volunteers. U.S. National Institutes of Health.
Ref 551215	A gift for research. SciBX 7(6); doi:10.1038/scibx.2014.160. Feb. 13 2014

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