Drug Information

Drug General Information
Drug ID
D01ILN
Former ID
DNC012813
Drug Name
6,7-Diphenyl-pteridine-2,4-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526601]
Structure
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2D MOL

3D MOL
Formula
C18H14N6
Canonical SMILES
C1=CC=C(C=C1)C2=NC3=C(N=C2C4=CC=CC=C4)N=C(N=C3N)N
InChI
1S/C18H14N6/c19-16-15-17(24-18(20)23-16)22-14(12-9-5-2-6-10-12)13(21-15)11-7-3-1-4-8-11/h1-10H,(H4,19,20,22,23,24)
InChIKey
DDZJPETYMUJLIW-UHFFFAOYSA-N
PubChem Compound ID
223355
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [526601]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 526601J Med Chem. 2003 Apr 24;46(9):1726-36.Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
Ref 526601J Med Chem. 2003 Apr 24;46(9):1726-36.Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.

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