Drug Information

Drug General Information
Drug ID
D01JHR
Former ID
DNC013062
Drug Name
H-Gly-dmP-Glu-OH
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528176]
Structure
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2D MOL

3D MOL
Formula
C14H23N3O6
Canonical SMILES
CC1(CCC(N1C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O)C
InChI
1S/C14H23N3O6/c1-14(2)6-5-9(17(14)10(18)7-15)12(21)16-8(13(22)23)3-4-11(19)20/h8-9H,3-7,15H2,1-2H3,(H,16,21)(H,19,20)(H,22,23)/t8-,9-/m0/s1
InChIKey
KNUZCBVWBGSPRA-IUCAKERBSA-N
PubChem Compound ID
11515428
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [528176]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [528176]
NMDA receptor subunit NR1 Target Info Inhibitor [528176]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Calcium signaling pathway
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 528176Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. Epub 2006 May 2.The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
Ref 528176Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. Epub 2006 May 2.The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

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