Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01KCF
|
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| Former ID |
DIB016474
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| Drug Name |
Small molecule 2a
|
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| Synonyms |
Vasopressin V1b receptor antagonists (depression); Vasopressin V1b receptor antagonists (depression), GlaxoSmithKline
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| Indication | Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] | Investigative | [1] | ||
| Company |
GlaxoSmithKline plc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
O=S(=O)(c1ccc(cc1)OC)N(Cc1nc(sc1)c1ccc(cc1)CNCCCC)C1CCO<br />CC1
|
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| Target and Pathway | |||||
| Target(s) | Vasopressin V1b receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Reactome | Vasopressin-like receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 367). | ||||
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