Drug Information

Drug General Information
Drug ID
D01NOZ
Former ID
DNC006946
Drug Name
ADS-103274
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528581]
Structure
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2D MOL

3D MOL
Formula
C22H26F3N5O2
Canonical SMILES
CN1C2=C(C=CC(=C2)NC(=O)COC3=CC=C(C=C3)C(F)(F)F)N=C1N(C)<br />CCN(C)C
InChI
1S/C22H26F3N5O2/c1-28(2)11-12-29(3)21-27-18-10-7-16(13-19(18)30(21)4)26-20(31)14-32-17-8-5-15(6-9-17)22(23,24)25/h5-10,13H,11-12,14H2,1-4H3,(H,26,31)
InChIKey
KMPCTCXLXOJTGD-UHFFFAOYSA-N
PubChem Compound ID
16665072
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Inhibitor [528581]
Melanin-concentrating hormone receptor 1 Target Info Inhibitor [528581]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.

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