Drug Information

Drug General Information
Drug ID
D01NTI
Former ID
DNC005311
Drug Name
N*2*-Benzyl-N*6*-cyclohexyl-9H-purine-2,6-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527647]
Structure
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2D MOL

3D MOL
Formula
C18H22N6
Canonical SMILES
C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NCC4=CC=CC=C4
InChI
1S/C18H22N6/c1-3-7-13(8-4-1)11-19-18-23-16-15(20-12-21-16)17(24-18)22-14-9-5-2-6-10-14/h1,3-4,7-8,12,14H,2,5-6,9-11H2,(H3,19,20,21,22,23,24)
InChIKey
NPPHTZNKBUCRPG-UHFFFAOYSA-N
PubChem Compound ID
15366659
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [527647]
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, Other
References
Ref 527647J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
Ref 527647J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

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