Drug Information

Drug General Information
Drug ID
D01NTM
Former ID
DNC003713
Drug Name
VER-5593
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527037]
Structure
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2D MOL

3D MOL
Formula
C12H17FN2S
Canonical SMILES
CC(CN1CCC2=CC(=C(C=C21)SC)F)N
InChI
1S/C12H17FN2S/c1-8(14)7-15-4-3-9-5-10(13)12(16-2)6-11(9)15/h5-6,8H,3-4,7,14H2,1-2H3/t8-/m0/s1
InChIKey
IGAAICGMRRWZJW-QMMMGPOBSA-N
PubChem Compound ID
11264955
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Inhibitor [527037]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527037]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [527037]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 527037Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70.Indoline derivatives as 5-HT(2C) receptor agonists.
Ref 527037Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70.Indoline derivatives as 5-HT(2C) receptor agonists.

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