Drug General Information
Drug ID
D01PAC
Former ID
DIB018160
Drug Name
[125I]L703,606
Synonyms
[125I]L703606; [125I]-L703,606
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540410]
Structure
Download
2D MOL
Formula
C27H29IN2
InChI
InChI=1S/C27H29IN2/c28-24-14-8-7-13-23(24)19-29-26-22-15-17-30(18-16-22)27(26)25(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-14,22,25-27,29H,15-19H2/t26-,27-/m1/s1/i28-2
InChIKey
WSLTYZVXORBNLB-BRXFWFLGSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [533970]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540410(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3471).
Ref 533970Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994 Jan;45(1):97-103.

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