Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01RBR
|
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| Former ID |
DIB001234
|
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| Drug Name |
SGS742
|
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| Indication | Schizophrenia [ICD9: 295; ICD10:F20] | Phase 2 | [1] | ||
| Company |
Saegis Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
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| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid B receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| GABAergic synapse | |||||
| Estrogen signaling pathway | |||||
| Morphine addiction | |||||
| Reactome | Activation of G protein gated Potassium channels | ||||
| G alpha (i) signalling events | |||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Potassium Channels | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol. 2004 Oct 15;68(8):1479-87. | ||||
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