Drug Information
Drug General Information | |||||
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Drug ID |
D01RUN
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Former ID |
DNC000014
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Drug Name |
(R)-Rolipram
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [537166] | ||
Structure |
Download2D MOL |
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Formula |
C16H21NO3
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Canonical SMILES |
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
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InChI |
1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
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InChIKey |
HJORMJIFDVBMOB-LBPRGKRZSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
7885372, 7885374, 10300167, 11111747, 11112814, 11113776, 11113777, 11113778, 12016200, 16133703, 36890033, 46392972, 46393090, 46507909, 46507984, 46508075, 50100342, 57404852, 76143228, 85789023, 87235809, 91746538, 93165425, 103332718, 103973669, 104224905, 104638908, 124881346, 124882649, 124882650, 124882651, 124882652, 126616648, 128070171, 134341264, 135266207, 135697605, 137009721, 142521916, 143494407, 144080082, 144220532, 152030706, 152164502, 152238532, 160779380, 160832182, 160965177, 162023069, 162183652
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Target and Pathway | |||||
Target(s) | CAMP-specific 3',5'-cyclic phosphodiesterase 4A | Target Info | Inhibitor | [537166] | |
CAMP-specific 3',5'-cyclic phosphodiesterase 4B | Target Info | Inhibitor | [537166] | ||
PDE4 | Target Info | Inhibitor | [535739], [537166] | ||
NetPath Pathway | IL5 Signaling Pathway | ||||
IL2 Signaling Pathway | |||||
References | |||||
Ref 535739 | Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. Anticancer Drugs. 2003 Jun;14(5):377-81. | ||||
Ref 537166 | PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. Epub 2009 Mar 20. |
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