Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01SJS
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| Former ID |
DIB016805
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| Drug Name |
AXL-1717
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| Synonyms |
BVT-51004; IGF-1 inhibitors, Axelar/Biovitrum; IGF-1 inhibitors, Karolinska/Biovitrum; Insulin-like growth factor 1 inhibitors, Axelar/Biovitrum
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| Drug Type |
Small molecular drug
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| Company |
Axelar AB
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| Structure |
|
Download2D MOL |
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| Formula |
C22H22O8
|
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| InChI |
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
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| InChIKey |
YJGVMLPVUAXIQN-HAEOHBJNSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
93086, 602433, 8138202, 8195191, 11364530, 11367092, 11369654, 11372800, 11375671, 11377816, 11484215, 11488336, 11491486, 11493650, 11495450, 11537779, 14831259, 14929033, 26612705, 26680654, 26758962, 29216394, 43128600, 47423461, 48317613, 48410508, 49971903, 50110901, 53787335, 57318718, 71831592, 78208362, 85787406, 91010625, 92124958, 92718093, 103192207, 104352939, 124637742, 126628593, 135148884, 142572795, 152104948, 162198638, 162248061, 163620930, 163686251, 163687885, 163835502, 174006597
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| Target and Pathway | |||||
| Target(s) | Insulin-like growth factor I receptor | Target Info | Inhibitor | [531096] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| FoxO signaling pathway | |||||
| Oocyte meiosis | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Signaling pathways regulating pluripotency of stem cells | |||||
| Long-term depression | |||||
| Ovarian steroidogenesis | |||||
| Progesterone-mediated oocyte maturation | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Proteoglycans in cancer | |||||
| Glioma | |||||
| Prostate cancer | |||||
| Melanoma | |||||
| References | |||||
| Ref 523845 | ClinicalTrials.gov (NCT01561456) Study of AXL1717 Compared to Docetaxel to Treat Squamous Cell Carcinoma or Adenocarcinoma of the Lung. U.S. National Institutes of Health. | ||||
| Ref 542799 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7873). | ||||
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