Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01TDC
|
||||
| Former ID |
DNC013705
|
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| Drug Name |
6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
|
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| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C5H10N2S
|
||||
| Canonical SMILES |
CC1CCN=C(S1)N
|
||||
| InChI |
1S/C5H10N2S/c1-4-2-3-7-5(6)8-4/h4H,2-3H2,1H3,(H2,6,7)
|
||||
| InChIKey |
BATVOUKHGLKDGQ-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Nitric oxide synthase, inducible | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Citrulline-nitric oxide cycle | ||||
| KEGG Pathway | Arginine biosynthesis | ||||
| Arginine and proline metabolism | |||||
| Metabolic pathways | |||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Peroxisome | |||||
| Salmonella infection | |||||
| Pertussis | |||||
| Leishmaniasis | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Toxoplasmosis | |||||
| Amoebiasis | |||||
| Tuberculosis | |||||
| Pathways in cancer | |||||
| Small cell lung cancer | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| Pathway Interaction Database | IL12-mediated signaling events | ||||
| Alpha9 beta1 integrin signaling events | |||||
| ATF-2 transcription factor network | |||||
| IL23-mediated signaling events | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| HIF-1-alpha transcription factor network | |||||
| Reactome | ROS production in response to bacteria | ||||
| Nitric oxide stimulates guanylate cyclase | |||||
| WikiPathways | Type II interferon signaling (IFNG) | ||||
| Spinal Cord Injury | |||||
| AGE/RAGE pathway | |||||
| Effects of Nitric Oxide | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 Jan 1;19(1):74-6. Epub 2008 Nov 12.Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. | ||||
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