Drug Information

Drug General Information
Drug ID
D01VPK
Former ID
DNC004618
Drug Name
FK-453
Drug Type
Small molecular drug
Indication Renal failure [ICD9: 584, 585; ICD10:N17, N18, N19] Discontinued in Phase 2 [540974], [544923]
Structure
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2D MOL

3D MOL
Formula
C23H25N3O2
InChI
InChI=1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m1/s1
InChIKey
OPLOPFHUHFGKMJ-JXOMPUQVSA-N
PubChem Compound ID
6439091
PubChem Substance ID
11968208, 12014332, 14926783, 43032043, 50016459, 52112115, 57368411, 103235118, 103971794, 114557756, 134341823, 135085036, 178102240, 228900931, 229124074
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Modulator
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540974(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5606).
Ref 544923Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001559)

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