Drug Information

Drug General Information
Drug ID
D01WXA
Former ID
DIB021064
Drug Name
TMB-8
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467661]
Structure
Download
2D MOL
Formula
C22H37NO5
InChI
InChI=1S/C22H37NO5/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4/h16-17H,6-15H2,1-5H3
InChIKey
IBQMHBGFMLHHLE-UHFFFAOYSA-N
PubChem Compound ID
5494
PubChem Substance ID
3139821, 4682454, 8153376, 11110668, 14756766, 26755645, 26755646, 29224537, 47365433, 47515555, 50064944, 50110926, 50110927, 53787761, 57322806, 80264075, 85788251, 90340968, 92309919, 99300833, 103567452, 103808264, 104309385, 117582090, 118498191, 124749388, 124879011, 124879012, 124879013, 124879014, 125715118, 128144559, 135061217, 137231118, 143545053, 162875813, 178101140, 184021159, 228306686, 241100547, 252455643
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Blocker (channel blocker) [525521]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 467661(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4323).
Ref 525521Characterization of interaction of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester with Torpedo californica nicotinic acetylcholine receptor and 5-hydroxytryptamine3 receptor. J Pharmacol Exp Ther. 1999 Jul;290(1):129-35.

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