Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01YDF
|
||||
| Former ID |
DIB015753
|
||||
| Drug Name |
Pibutidine
|
||||
| Synonyms |
Alex; Pibutidine hydrochloride; IT-066
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Ulcerative colitis [ICD9: 556; ICD10:K51] | Discontinued in Phase 3 | [1] | ||
| Company |
Ikeda Mohando Co Ltd
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H24N4O3
|
||||
| Canonical SMILES |
C1(=C(C(=O)C1=O)N)NC/C=C\COc1nccc(CN2CCCCC2)c1.Cl
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretion | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Histamine H2 receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
| Gastric Acid Production | |||||
| Reactome | Histamine receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000641) | ||||
| REF 2 | Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.