Drug Information
Drug General Information | |||||
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Drug ID |
D01YDF
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Former ID |
DIB015753
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Drug Name |
Pibutidine
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Synonyms |
Alex; Pibutidine hydrochloride; IT-066
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Drug Type |
Small molecular drug
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Indication | Ulcerative colitis [ICD9: 556; ICD10:K51] | Discontinued in Phase 3 | [1] | ||
Company |
Ikeda Mohando Co Ltd
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Structure |
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Download2D MOL |
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Formula |
C19H24N4O3
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Canonical SMILES |
C1(=C(C(=O)C1=O)N)NC/C=C\COc1nccc(CN2CCCCC2)c1.Cl
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H2 receptor | Target Info | Modulator | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (s) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000641) | ||||
REF 2 | Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82. | ||||
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