Drug General Information
Drug ID
D02AUB
Former ID
DCL000069
Drug Name
Bimosiamose
Synonyms
TBC 1269; TBC-1269
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease; Psoriatic disorder; Atopic dermatitis [ICD9: 490-492, 494-496, 691.8, 692.9, 696; ICD10:J40-J44, J47, L20, L20-L30, L40] Phase 2a [536958]
Asthma [ICD10:J45] Phase 2 [536958]
Company
Encysive Pharma
Structure
Download
2D MOL

3D MOL

Formula
C46H54O16
Canonical SMILES
C1=CC(=CC(=C1)CC(=O)O)C2=C(C=CC(=C2)CCCCCCC3=CC(=C(C=C3<br />)OC4C(C(C(C(O4)CO)O)O)O)C5=CC(=CC=C5)CC(=O)O)OC6C(C(C(C<br />(O6)CO)O)O)O
InChI
1S/C46H54O16/c47-23-35-39(53)41(55)43(57)45(61-35)59-33-15-13-25(19-31(33)29-11-5-9-27(17-29)21-37(49)50)7-3-1-2-4-8-26-14-16-34(60-46-44(58)42(56)40(54)36(24-48)62-46)32(20-26)30-12-6-10-28(18-30)22-38(51)52/h5-6,9-20,35-36,39-48,53-58H,1-4,7-8,21-24H2,(H,49,50)(H,51,52)/t35-,36-,39-,40-,41+,42+,43+,44+,45+,46+/m1/s1
InChIKey
RYWCQJDEHXJHRI-XJMXIVSISA-N
CAS Number
CAS 187269-40-5
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) E-selectin Target Info Inhibitor [536136], [536502], [536763]
KEGG Pathway Cell adhesion molecules (CAMs)
TNF signaling pathway
African trypanosomiasis
Malaria
NetPath Pathway IL5 Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
ID Signaling Pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
ATF-2 transcription factor network
Reactome Cell surface interactions at the vascular wall
WikiPathways Human Complement System
TNF alpha Signaling Pathway
Cell surface interactions at the vascular wall
References
Ref 536958Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
Ref 536136Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial. Pulm Pharmacol Ther. 2006;19(4):233-41. Epub 2005 Sep 1.
Ref 536502The pharmacokinetics of subcutaneously injected Bimosiamose disodium in healthy male volunteers. Biopharm Drug Dispos. 2007 Dec;28(9):475-84.
Ref 536763Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. Shock. 2008 Apr;29(4):475-82.

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