Drug General Information
Drug ID	D02BRJ
Former ID	DIB010659
Drug Name	Vabicaserin
Synonyms	Vabicaserin hydrochloride; PF-05208769; PF-5208769; SCA-136; WY-16629
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Phase 2	[522459]
Company	Wyeth
Structure		Download 2D MOL 3D MOL
Formula	C15H20N2
Canonical SMILES	N12c3c(CNCC1)cccc3[C@@H]1[C@H](C2)CCC1
PubChem Compound ID	11521822
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Modulator	[531390]
	5-hydroxytryptamine 2C receptor	Target Info	Modulator	[531390]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	GPCR downstream signaling
References
Ref 522459	ClinicalTrials.gov (NCT00768612) Study Evaluating Safety and Tolerability of Vabicaserin in Patients With Sudden Worsening of Schizophrenia. U.S. National Institutes of Health.
Ref 531390	Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist. J Pharmacol Exp Ther. 2011 Jun;337(3):673-80.

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