Drug Information

Drug General Information
Drug ID
D02CQN
Former ID
DNC011257
Drug Name
5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531169]
Structure
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2D MOL

3D MOL
Formula
C20H17ClN2O
Canonical SMILES
CC1=CC=CC=C1CNC(=O)C2=CN=CC(=C2)C3=CC=C(C=C3)Cl
InChI
1S/C20H17ClN2O/c1-14-4-2-3-5-16(14)13-23-20(24)18-10-17(11-22-12-18)15-6-8-19(21)9-7-15/h2-12H,13H2,1H3,(H,23,24)
InChIKey
MLDMXXWILKZITA-UHFFFAOYSA-N
PubChem Compound ID
52945923
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Inhibitor [531169]
PN3 Na+ channel Target Info Inhibitor [531169]
Reactome Interaction between L1 and Ankyrins
References
Ref 531169Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Ref 531169Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. Epub 2010 Sep 18.Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

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