Drug Information
Drug General Information | |||||
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Drug ID |
D02EMR
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Former ID |
DCL000752
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Drug Name |
Cilomilast
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Synonyms |
Ariflo; CIO; SB 207499; SB207499; Ariflo (TN); Cilomilast [USAN:INN]; SB-207499; Ariflo, SB-207499,Cilomilast; Cilomilast (JAN/USAN/INN); CIS-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANECARBOXYLIC ACID; Cis-4-Cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexanecarboxylic acid; Cis-4-Cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid; Cis-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-4-cyanocyclohexane-1-carboxylic acid; 4-cyano-4-(3-cyclopentoxy-4-methoxy-phenyl)-cyclohexane-1-carboxylic acid; 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
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Drug Type |
Small molecular drug
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Indication | Emphysema; Bronchitis; Chronic obstructive pulmonary disease [ICD9: 460-519, 466, 490, 490-492, 491, 492, 494-496; ICD10:J00-J99, J20-J21, J40-J44, J42, J43, J47] | Discontinued in Phase 3 | [536958], [542430] | ||
Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] | Discontinued in Phase 2 | [536958], [542430] | |||
Company |
GlaxoSmithKline
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Structure |
Download2D MOL |
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Formula |
C20H25NO4
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InChI |
InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-
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InChIKey |
CFBUZOUXXHZCFB-OYOVHJISSA-N
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CAS Number |
CAS 153259-65-5
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PubChem Compound ID | |||||
PubChem Substance ID |
7848767, 7886612, 10251041, 12014847, 14827338, 14900458, 15722497, 40967267, 40967286, 46227735, 46393565, 46393575, 46505062, 46515098, 47657134, 48105226, 49957697, 50112773, 53790097, 57347308, 80059282, 93308090, 93310591, 99437274, 103587454, 103994769, 104430347, 124757262, 125164066, 125536625, 127615918, 127615919, 127615920, 131300126, 131349019, 131480881, 134339242, 135106954, 136367428, 136367988, 137102438, 137246277, 140119543, 141754319, 141948760, 144115831, 144206070, 152106616, 152258266, 152344295
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Target and Pathway | |||||
Target(s) | PDE4 | Target Info | Inhibitor | [536223] | |
CAMP-specific 3',5'-cyclic phosphodiesterase 4A | Target Info | Inhibitor | [536958] | ||
WikiPathways | G Protein Signaling Pathways | ||||
References | |||||
Ref 536958 | Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53. | ||||
Ref 542430 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7407). |
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