TTD | Drug: D02FEA

Drug General Information
Drug ID	D02FEA
Former ID	DNC011273
Drug Name	FENDILINE
Drug Type	Small molecular drug
Indication	Coronary heart disease [ICD9: 414; ICD10:I25.1]		Withdrawn from market	[533443]
Structure		Download 2D MOL 3D MOL
Formula	C23H25N
Canonical SMILES	CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
InChI	1S/C23H25N/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,19,23-24H,17-18H2,1H3
InChIKey	NMKSAYKQLCHXDK-UHFFFAOYSA-N
CAS Number	CAS 13042-18-7
PubChem Compound ID	3336
SuperDrug ATC ID	C08EA01
Target and Pathway
Target(s)	5-hydroxytryptamine 2B receptor	Target Info	Inhibitor	[531223]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 533443	Value of fendiline in the treatment of patients with stable angina pectoris. Pol Tyg Lek. 1987 Nov 16;42(46):1456-8.
Ref 531223	J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

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Drug Information