Drug Information

Drug General Information
Drug ID
D02FZD
Former ID
DNC000017
Drug Name
(S)-Rolipram
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537166]
Structure
Download
2D MOL

3D MOL
Formula
C16H21NO3
Canonical SMILES
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
InChI
1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
InChIKey
HJORMJIFDVBMOB-GFCCVEGCSA-N
CAS Number
CAS 216974-75-3
PubChem Compound ID
158758
PubChem Substance ID
7890298, 10253420, 12085819, 16376270, 46234139, 46392830, 46393570, 57348541, 76143230, 81061690, 85197718, 85787603, 91746537, 93581517, 103333097, 103973667, 104253460, 113440732, 124757590, 125164394, 128070170, 135114129, 135697606, 136348713, 136367568, 136946610, 137133766, 142521914, 152137936, 152198696, 162023071, 162037764, 162201769, 163137913, 176484875, 198938016, 198939252, 210279538, 210281861, 223516226, 223705241, 231162484, 241182352, 241375374, 252160141, 252220216
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [537166]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [537166]
PDE4 Target Info Inhibitor [535739], [537166]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 537166PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. Epub 2009 Mar 20.
Ref 535739Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. Anticancer Drugs. 2003 Jun;14(5):377-81.
Ref 537166PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. Epub 2009 Mar 20.

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