Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02GNL
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| Former ID |
DIB003088
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| Drug Name |
KMJ-372
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| Synonyms |
KMJ-372; MK-271; TRPV1 antagonists (pain); TRPV1 antagonists (pain), Digital Biotech/Grunenthal; TRPV1 antagonists (pain), Medifron/Grunenthal; VR1 antagonists (pain), Digital Biotech/Grunenthal; Vanilloid antagonists (analgesic), Digital Biotech/Grunenthal; (S)-KMJ-372
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Investigative | [1] | ||
| Company |
Digital Biotech Co Ltd
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C(=O)(C(C)c1cc(c(cc1)NS(=O)(=O)C)F)NCc1ccc(cc1)C(C)(C)C
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| Target and Pathway | |||||
| Target(s) | Vanilloid receptor 1 | Target Info | Antagonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). | ||||
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