Drug General Information
Drug ID
D02IHW
Former ID
DIB003293
Drug Name
Nepafenac
Synonyms
Nevanac; AHR-9434; AL-6515
Drug Type
Small molecular drug
Indication Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] Approved [542564], [551186], [551871]
Company
Alcon
Structure
Download
2D MOL

3D MOL

Formula
C15H14N2O2
InChI
InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChIKey
QEFAQIPZVLVERP-UHFFFAOYSA-N
CAS Number
CAS 78281-72-8
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Cyclooxygenase Target Info Inhibitor [526496], [551871]
References
Ref 542564(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7564).
Ref 5511862005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526496Topical nepafenac inhibits ocular neovascularization. Invest Ophthalmol Vis Sci. 2003 Jan;44(1):409-15.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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