| Drug General Information |
| Drug ID |
D02KIS
|
| Former ID |
DNC012503
|
| Drug Name |
(S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H13N
|
| Canonical SMILES |
CC1CC2=CC=CC=C2CN1
|
| InChI |
1S/C10H13N/c1-8-6-9-4-2-3-5-10(9)7-11-8/h2-5,8,11H,6-7H2,1H3/t8-/m0/s1
|
| InChIKey |
UEKQPSAKUNXFHL-QMMMGPOBSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
| Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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PANTHER Pathway
|
Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Reactome
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Adrenoceptors
|
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Adrenaline signalling through Alpha-2 adrenergic receptor
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Adrenaline,noradrenaline inhibits insulin secretion
|
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G alpha (i) signalling events
|
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G alpha (z) signalling events
|
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Surfactant metabolismR-HSA-390696:Adrenoceptors
|
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
|
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Surfactant metabolism
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WikiPathways
|
Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
|
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Platelet Aggregation (Plug Formation)
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Integration of energy metabolism
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
|
|
GPCR downstream signaling
|
| References |
| REF 1 | J Med Chem. 1996 Aug 30;39(18):3539-46.Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase. |
|---|
