Drug Information

Drug General Information
Drug ID
D02LWU
Former ID
DAP001549
Drug Name
Pralatrexate
Synonyms
Folotyn (TN)
Drug Type
Small molecular drug
Indication Peripheral T-cell lymphoma; Breast cancer [ICD9: 202.7, 174, 175; ICD10:C84.4, C50] Approved [530677], [541920], [551871]
Company
Allos Therapeutics
Structure
Download
2D MOL

3D MOL
Formula
C23H23N7O5
InChI
InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
InChIKey
OGSBUKJUDHAQEA-WMCAAGNKSA-N
CAS Number
CAS 146464-95-1
PubChem Compound ID
148121
PubChem Substance ID
10249810, 14761163, 14907808, 46225076, 47207252, 57346701, 76049103, 99437279, 103771482, 104418267, 124950714, 126666101, 131408688, 134223179, 135692165, 136367814, 137248707, 141792755, 144206459, 144236486, 152106310, 152258219, 152344466, 160646081, 160647055, 164044033, 164232763, 164764489, 175427094, 175437712, 176484650, 178103446, 180191813, 184527271, 186014781, 198993109, 223392464, 223659651, 223702389, 225255488, 226410872, 240035409, 241036657, 243124404, 249868098, 252069088, 252214139, 252473148
SuperDrug ATC ID
L01BA05
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [530677]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 541920(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6840).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.

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