Drug Information

Drug General Information
Drug ID
D02NEH
Former ID
DAP001483
Drug Name
Ibutamoren
Synonyms
L 163191; MK-0667; MK-677; 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
Drug Type
Small molecular drug
Indication Fibromyalgia [ICD9: 729.1; ICD10:M79.7] Approved [536647], [541176]
Company
Merck
Structure
Download
2D MOL

3D MOL
Formula
C27H36N4O5S
InChI
InChI=1S/C27H36N4O5S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27/h4-12,22H,13-19,28H2,1-3H3,(H,29,33)/t22-/m1/s1
InChIKey
UMUPQWIGCOZEOY-JOCHJYFZSA-N
CAS Number
CAS 159634-47-6
PubChem Compound ID
178024
PubChem Substance ID
10258837, 14763096, 14860934, 33501352, 80929562, 99437004, 103175631, 103979794, 104426867, 129390870, 134338675, 135155448, 137031143, 137275959, 140372504, 152344355, 163352648, 178102491, 179150023, 198966446, 223660631, 227026040, 252215561
Target and Pathway
Target(s) Growth hormone secretagogue receptor type 1 Target Info Modulator [553238]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway Leptin Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536647Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62.
Ref 541176(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5867).
Ref 553238Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol Endocrinol. 1996 Jan;10(1):57-61.

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