Drug Information

Drug General Information
Drug ID
D02OAJ
Former ID
DIB021145
Drug Name
UTPgammaS
Synonyms
UTPgammaS; UTPgammaS
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539087]
Structure
Download
2D MOL
Formula
C9H15N2O14P3S
InChI
InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(23-8)3-22-26(16,17)24-27(18,19)25-28(20,21)29/h1-2,4,6-8,13-14H,3H2,(H,16,17)(H,18,19)(H,10,12,15)(H2,20,21,29)/t4-,6-,7-,8-/m1/s1
InChIKey
DUDALCZPYHIGIR-XVFCMESISA-N
PubChem Compound ID
5311494
PubChem Substance ID
7980870, 14859920, 39341160, 51509881, 57359502, 103509213, 114156217, 127787309, 131341273, 135651593, 226673867
Target and Pathway
Target(s) P2Y purinoceptor 2 Target Info Agonist [534088]
P2Y4 receptor Target Info Agonist [534221]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL5 Signaling Pathway
Reactome G alpha (q) signalling events
P2Y receptors
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539087(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1735).
Ref 534088Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol. 1995 Sep;116(1):1619-27.
Ref 534221Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br J Pharmacol. 1996 Jan;117(1):203-9.

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