Drug Information

Drug General Information
Drug ID
D02ORS
Former ID
DIB005881
Drug Name
YKP-GI
Synonyms
SKL-IBS; YKP-10811; 5-HT 4 receptor partial agonist (irritable bowel syndrome/constipation), SK Life science
Drug Type
Small molecular drug
Indication Constipation [ICD9: 564; ICD10:K59.0] Phase 2 [524531], [543129]
Company
SK Life Science
Structure
Download
2D MOL
Formula
C24H30ClFN4O4
InChI
InChI=1S/C24H30ClFN4O4/c1-33-22-13-20(27)19(25)12-18(22)23(31)29-14-15-6-9-30(10-7-15)11-8-21(34-24(28)32)16-2-4-17(26)5-3-16/h2-5,12-13,15,21H,6-11,14,27H2,1H3,(H2,28,32)(H,29,31)/t21-/m0/s1
InChIKey
KGMMSPVVHZGPHL-NRFANRHFSA-N
PubChem Compound ID
45275554
PubChem Substance ID
92757933, 120274187, 165224877, 228455500, 252166637
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [532929]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 524531ClinicalTrials.gov (NCT01989234) A Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week, Dose-Range-Finding Trial of YKP10811 Capsules Administered Once Daily to Subjects With Chronic Idiopathic Constipation. U.S. National Institutes of Health.
Ref 543129(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8427).
Ref 532929A randomized trial of 5-hydroxytryptamine4-receptor agonist, YKP10811, on colonic transit and bowel function in functional constipation. Clin Gastroenterol Hepatol. 2015 Apr;13(4):701-8.e1.

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