Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02QJW
|
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| Former ID |
DIB019152
|
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| Drug Name |
clofilium
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C21H37ClN+
|
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| InChI |
InChI=1S/C21H37ClN/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20/h14-17H,4-13,18-19H2,1-3H3/q+1
|
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| InChIKey |
WPSYTTKBGAZSCX-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
854018, 4302950, 7980451, 8151807, 11467467, 11486273, 29221953, 47216986, 47515532, 47589186, 47589187, 49698434, 50070299, 50070958, 50113156, 50113157, 50315463, 53801073, 57321467, 92098481, 103168791, 104040003, 104301643, 126407453, 129616320, 131333045, 135065239, 137231979, 141640747, 142611651, 162220962, 162633875, 179150928, 198985509, 223442442, 226521405, 244578489, 252661029
|
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| Target and Pathway | |||||
| Target(s) | Potassium voltage-gated channel subfamily A member 5 | Target Info | Blocker (channel blocker) | [2] | |
| Kv10.1 | Target Info | Blocker (channel blocker) | [3] | ||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Voltage gated Potassium channels | ||||
| WikiPathways | Potassium Channels | ||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2507). | ||||
| REF 2 | Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel. Mol Pharmacol. 1995 Jan;47(1):198-205. | ||||
| REF 3 | Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol. 2003 Jan;138(1):161-71. | ||||
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