Drug Information

Drug General Information
Drug ID
D02SBM
Former ID
DNC011280
Drug Name
6-(piperazin-1-yl)-3-tosyl-1H-indazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531198]
Structure
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2D MOL

3D MOL
Formula
C18H20N4O2S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)C2=C3C=CC(=CC3=NN2)N4CCNCC4
InChI
1S/C18H20N4O2S/c1-13-2-5-15(6-3-13)25(23,24)18-16-7-4-14(12-17(16)20-21-18)22-10-8-19-9-11-22/h2-7,12,19H,8-11H2,1H3,(H,20,21)
InChIKey
HACUZCXCVMCHQD-UHFFFAOYSA-N
PubChem Compound ID
49836719
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [531198]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 531198J Med Chem. 2010 Nov 11;53(21):7639-46.5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.
Ref 531198J Med Chem. 2010 Nov 11;53(21):7639-46.5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists.

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