Drug General Information
Drug ID	D02SMG
Former ID	DNC007247
Drug Name	2-(furan-2-yl)-6-morpholino-4H-pyran-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528738]
Structure		Download 2D MOL 3D MOL
Formula	C13H13NO4
Canonical SMILES	C1COCCN1C2=CC(=O)C=C(O2)C3=CC=CO3
InChI	1S/C13H13NO4/c15-10-8-12(11-2-1-5-17-11)18-13(9-10)14-3-6-16-7-4-14/h1-2,5,8-9H,3-4,6-7H2
InChIKey	AHAIOLWQJGMAQA-UHFFFAOYSA-N
PubChem Compound ID	16203943
Target and Pathway
Target(s)	DNA-dependent protein kinase catalytic subunit	Target Info	Inhibitor	[528738]
KEGG Pathway	Non-homologous end-joining
	Cell cycle
NetPath Pathway	IL1 Signaling Pathway
Pathway Interaction Database	DNA-PK pathway in nonhomologous end joining
	Coregulation of Androgen receptor activity
	Class I PI3K signaling events mediated by Akt
	BARD1 signaling events
Reactome	Nonhomologous End-Joining (NHEJ)
WikiPathways	DNA Damage Response
	Non-homologous end joining
	FAS pathway and Stress induction of HSP regulation
	Cytosolic sensors of pathogen-associated DNA
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Double-Strand Break Repair
	Cell Cycle
	miRNA Regulation of DNA Damage Response
References
Ref 528738	J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738	J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.

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