Drug General Information
Drug ID	D02WRO
Former ID	DIB012700
Drug Name	11-beta-HSD1 inhibitors
Synonyms	11beta-hydroxysteroid dehydrogenase-1 inhibitors (metabolic disorder), Sanofi
Indication	Metabolic disorders [ICD9: 270-279; ICD10:E70-E89]		Investigative	[552167]
Company	Sanofi
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cccc2c1N(CCN2c1ncc(cn1)c1ccc(cc1)OC)C(=O)N1CCC(C1)c1c<br />n[nH]c1
Target and Pathway
Target(s)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	Target Info	Inhibitor	[543704]
KEGG Pathway	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways
	Chemical carcinogenesis
NetPath Pathway	IL1 Signaling Pathway
	FSH Signaling Pathway
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
WikiPathways	Prostaglandin Synthesis and Regulation
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 552167	WO patent application no. 2006134481, INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1.
Ref 543704	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763).

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