Drug General Information
Drug ID
D02YSX
Former ID
DNC010278
Drug Name
DIMEBOLIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530547]
Structure
Download
2D MOL

3D MOL

Formula
C21H25N3
Canonical SMILES
CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C
InChI
1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
InChIKey
JNODQFNWMXFMEV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [530540]
Histamine H1 receptor Target Info Inhibitor [530547]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04385:Histamine H1 receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 530547Bioorg Med Chem Lett. 2010 Jan 1;20(1):78-82. Epub 2009 Nov 14.Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
Ref 530540Eur J Med Chem. 2010 Feb;45(2):782-9. Epub 2009 Oct 31.8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.
Ref 530547Bioorg Med Chem Lett. 2010 Jan 1;20(1):78-82. Epub 2009 Nov 14.Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.