Drug Information

Drug General Information
Drug ID
D02YYF
Former ID
DAP000939
Drug Name
Bretylium
Synonyms
Bretylum; Bretylium tolsylate; Bretylium tosylate(USAN); N-(2-bromobenzyl)-N,N-dimethylethanaminium; N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium; Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1); (2-bromobenzyl)ethyldimethylaminium; (2-bromophenyl)methyl-ethyl-dimethylazanium; (o-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate; 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium
Drug Type
Small molecular drug
Indication Ventricular fibrillation [ICD10:I49.01] Approved [551871]
Therapeutic Class
Antiarrhythmic Agents
Company
Hospira Inc
Structure
Download
2D MOL

3D MOL
Formula
C11H17BrN+
InChI
InChI=1S/C11H17BrN/c1-4-13(2,3)9-10-7-5-6-8-11(10)12/h5-8H,4,9H2,1-3H3/q+1
InChIKey
AAQOQKQBGPPFNS-UHFFFAOYSA-N
CAS Number
CAS 59-41-6
PubChem Compound ID
2431
PubChem Substance ID
9073, 794516, 5580995, 7978814, 8151623, 11468090, 11486799, 14749639, 29221595, 46505320, 47365410, 47515523, 47515524, 48035343, 49699004, 50064953, 50113154, 50113155, 50310316, 57321311, 85209526, 92740966, 104300566, 126407358, 126729469, 127378478, 131273742, 134222665, 134338214, 135021960, 137001461, 142246611, 160964492, 162201420, 175267511, 178103706, 179225252, 223454297, 223518984, 223814627, 225144298, 226405825, 246089195
SuperDrug ATC ID
C01BD02
SuperDrug CAS ID
cas=000061756
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Antagonist [537646], [537704]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537646Dissociation of autonomic controls of heart rate in weaning-aged borderline hypertensive rats by perinatal NaCl. J Auton Nerv Syst. 1990 Mar;29(3):219-26.
Ref 537704Components of functional sympathetic control of heart rate in neonatal rats. Am J Physiol. 1985 May;248(5 Pt 2):R601-10.

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