Drug Information

Drug General Information
Drug ID
D03GCJ
Former ID
DAP000065
Drug Name
Carteolol
Synonyms
Carteololum; Carteolol HCl; Carteolol Monohydrochloride; Arteolol (TN); Arteoptic (TN); Calte (TN); Carteol (TN); Carteolol (INN); Carteolol [INN:BAN]; Carteololum [INN-Latin]; Cartrol (TN); Elebloc (TN); Endak (TN); Glauteolol (TN); Mikelan (TN); Ocupress (TN); Poenglaucol (TN); Singlauc (TN); Teoptic (TN); 5-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}oxy)-3,4-dihydroquinolin-2(1H)-one; 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one; 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Approved [551871]
Therapeutic Class
Antihypertensive Agents
Company
CIBA Vision Sterile Mfg
Structure
Download
2D MOL

3D MOL
Formula
C16H24N2O3
InChI
InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20)
InChIKey
LWAFSWPYPHEXKX-UHFFFAOYSA-N
CAS Number
CAS 51781-06-7
PubChem Compound ID
2583
PubChem Substance ID
9091, 7387302, 7978865, 8151708, 11466474, 11467594, 11486167, 14849226, 29221743, 46507513, 47676636, 47750978, 48049811, 48199247, 48273825, 48415706, 49699359, 50043719, 50124258, 51091932, 56464106, 57321385, 74586165, 85209493, 85788887, 99246440, 103220917, 103972128, 104301010, 125351949, 126686934, 128549615, 134223610, 134337393, 135001302, 137248593, 142047552, 152057655, 160963866, 163164682, 163419007, 164829321, 172892987, 178103718, 179150538, 184536606, 198992672, 223672177, 226413058, 241091236
ChEBI ID
ChEBI:3437
SuperDrug ATC ID
C07AA15; S01ED05
SuperDrug CAS ID
cas=051781067
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Agonist [535096], [536812]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535096Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus. Jpn J Pharmacol. 2000 Nov;84(3):287-92.
Ref 536812Effects of prolonged treatment with beta-adrenoceptor antagonist, carteolol on systemic and regional hemodynamics in stroke-prone spontaneously hypertensive rats. J Pharmacobiodyn. 1991 Feb;14(2):94-100.

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