Drug General Information
Drug ID	D03JHJ
Former ID	DIB008335
Drug Name	FK-352
Synonyms	FK-325B; FK-352B
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Discontinued in Phase 2	[545925]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C23H23N3O3
Canonical SMILES	c1(c(nn2c1cccc2)c1ccccc1)/C=C/C(=O)N1[C@@H](CC(=O)O)CCC<br />C1
CAS Number	CAS 143881-08-7
PubChem Compound ID	6442241
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Antagonist	[527956]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545925	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005374)
Ref 527956	Adenosine A1 receptor antagonist improves intradialytic hypotension. Kidney Int. 2006 Mar;69(5):877-83.

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