Drug Information

Drug General Information
Drug ID
D03KNI
Former ID
DIB019929
Drug Name
GR 125487
Synonyms
GR-125487; GR125487
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539604]
Structure
Download
2D MOL
Formula
C19H26FN3O5S
InChI
InChI=1S/C19H26FN3O5S/c1-27-18-17(15-11-14(20)3-4-16(15)22-18)19(24)28-12-13-5-8-23(9-6-13)10-7-21-29(2,25)26/h3-4,11,13,21-22H,5-10,12H2,1-2H3
InChIKey
SSPCCAYAIDNNJX-UHFFFAOYSA-N
PubChem Compound ID
4284721
PubChem Substance ID
6290686, 9627881, 14782929, 35542783, 79128868, 85214569, 103653702, 112845782, 124749827, 129282813, 135650310, 136351120, 137022983, 142607967, 160827893, 163093370, 163391347, 163842073, 172854307, 179149935, 189658554, 204435065, 223532820, 229003649, 252215487
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [534287]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539604(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 248).
Ref 534287Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor. FEBS Lett. 1996 Nov 25;398(1):19-25.

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