Drug Information

Drug General Information
Drug ID
D03KPA
Former ID
DNC004559
Drug Name
5-Ethyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525845]
Structure
Download
2D MOL

3D MOL
Formula
C16H22N2
Canonical SMILES
CCC1=CC2=C(C=C1)NC=C2CCN3CCCC3
InChI
1S/C16H22N2/c1-2-13-5-6-16-15(11-13)14(12-17-16)7-10-18-8-3-4-9-18/h5-6,11-12,17H,2-4,7-10H2,1H3
InChIKey
PWLIYMBPGFVKOO-UHFFFAOYSA-N
PubChem Compound ID
15870567
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Inhibitor [525845]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [525845]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 525845Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9.5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists.
Ref 525845Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9.5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists.

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