Drug Information

Drug General Information
Drug ID
D03LWV
Former ID
DNC012979
Drug Name
Nle-Pro-Glu
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527903]
Structure
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2D MOL

3D MOL
Formula
C16H27N3O6
Canonical SMILES
CCCCC(C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)O)N
InChI
1S/C16H27N3O6/c1-2-3-5-10(17)15(23)19-9-4-6-12(19)14(22)18-11(16(24)25)7-8-13(20)21/h10-12H,2-9,17H2,1H3,(H,18,22)(H,20,21)(H,24,25)/t10-,11-,12-/m0/s1
InChIKey
SGASVGGGJFNOSL-SRVKXCTJSA-N
PubChem Compound ID
44408687
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [527903]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [527903]
NMDA receptor subunit NR1 Target Info Inhibitor [527903]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Calcium signaling pathway
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 527903Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6.New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
Ref 527903Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6.New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.

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