Drug Information

Drug General Information
Drug ID
D03MEI
Former ID
DNC013928
Drug Name
VU0080241
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541397]
Structure
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2D MOL

3D MOL
Formula
C19H23N5
InChI
InChI=1S/C19H23N5/c1-13-6-7-17(15(3)9-13)24-19-16(10-22-24)18(20-12-21-19)23-8-4-5-14(2)11-23/h6-7,9-10,12,14H,4-5,8,11H2,1-3H3
InChIKey
CLQVVBPDAXJGBV-UHFFFAOYSA-N
PubChem Compound ID
3260619
PubChem Substance ID
4290274, 7971148, 9247835, 24283525, 26726296, 28339350, 34634992, 47671646, 48268813, 52238220, 88223753, 103625164, 104111923, 106635246, 111848100, 124806731, 124889386, 134351133, 164089090, 164875761, 167508666, 178102848, 179337085, 179432763, 217498007
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Inhibitor [529695]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 541397(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6227).
Ref 529695Bioorg Med Chem Lett. 2008 Oct 15;18(20):5626-30. Epub 2008 Aug 29.Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators.

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