Drug Information

Drug General Information
Drug ID
D03MIN
Former ID
DIB011615
Drug Name
M-0004
Synonyms
Gastroprokinetic compound (pediatric reflux), Janssen; Gastroprokinetic compound (pediatric reflux), Movetis
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Phase 1 [548565]
Company
Janssen Pharmaceutica NV
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [543971]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 548565Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026666)
Ref 543971(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9).

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