Drug General Information
Drug ID	D03MNS
Former ID	DIB012911
Drug Name	ADL-7445
Synonyms	Mu-opioid antagonists (opioid-induced bowel disorder), Adolor; 14-beta-aminonaltrexone
Indication	Constipation [ICD9: 564; ICD10:K59.0]		Discontinued in Phase 1	[548993]
Company	Adolor Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@]123[C@@]4([C@H](N(CC5CC5)CC3)Cc3c1c(O[C@H]2C(=O)CC4<br />)c(cc3)O)N
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Antagonist	[531510]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548993	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031260)
Ref 531510	Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56.

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