Drug General Information
Drug ID	D03MVY
Former ID	DNC004434
Drug Name	2-(5-Thiophen-2-yl-1H-indol-3-yl)-ethylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525792]
Structure		Download 2D MOL 3D MOL
Formula	C14H14N2S
Canonical SMILES	C1=CSC(=C1)C2=CC3=C(C=C2)NC=C3CCN
InChI	1S/C14H14N2S/c15-6-5-11-9-16-13-4-3-10(8-12(11)13)14-2-1-7-17-14/h1-4,7-9,16H,5-6,15H2
InChIKey	KULFBKTWESBCBG-UHFFFAOYSA-N
PubChem Compound ID	10198700
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[525792]
	5-hydroxytryptamine 1B receptor	Target Info	Inhibitor	[525792]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signaling
References
Ref 525792	Bioorg Med Chem Lett. 2000 May 1;10(9):903-5.5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.
Ref 525792	Bioorg Med Chem Lett. 2000 May 1;10(9):903-5.5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.

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