Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03OFO
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| Former ID |
DNC012138
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| Drug Name |
L-768673
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C27H18F9N3O2
|
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC(C(=O)N(C3=CC=CC=C32)CC(F)(F)F)NC(=O)<br />CC4=C(C=C(C=C4)C(F)(F)F)C(F)(F)F
|
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| InChI |
1S/C27H18F9N3O2/c28-25(29,30)14-39-20-9-5-4-8-18(20)22(15-6-2-1-3-7-15)38-23(24(39)41)37-21(40)12-16-10-11-17(26(31,32)33)13-19(16)27(34,35)36/h1-11,13,23H,12,14H2,(H,37,40)/t23-/m1/s1
|
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| InChIKey |
VVCYJFVTVHMTBV-HSZRJFAPSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Potassium voltage-gated channel subfamily KQT member 1 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | ||||
| Cholinergic synapse | |||||
| Gastric acid secretion | |||||
| Pancreatic secretion | |||||
| Protein digestion and absorption | |||||
| Vibrio cholerae infection | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Voltage gated Potassium channels | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Potassium Channels | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| TarBasePathway | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009178) | ||||
| REF 2 | J Med Chem. 1997 Nov 21;40(24):3865-8.Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide. | ||||
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