Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03QGB
|
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| Former ID |
DNC002348
|
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| Drug Name |
JNJ-5207852
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| Drug Type |
Small molecular drug
|
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| Indication | Narcolepsy [ICD9: 347; ICD10:G47.4] | Investigative | [1] | ||
| Company |
Johnson & Johnson
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C20H32N2O
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| InChI |
InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2
|
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| InChIKey |
PTKHFRNHJULJKT-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3196602, 5392837, 8302527, 14821295, 25782704, 39181268, 49665761, 78415116, 85227379, 88728348, 103361523, 103856695, 104045710, 109623889, 111376115, 125163397, 125444230, 135649651, 137128903, 139563581, 162507776, 172113486, 172919121, 179524509, 187581008, 198982782, 224053991, 229581697, 247251069
|
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| Target and Pathway | |||||
| Target(s) | Histamine H3 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1256). | ||||
| REF 2 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | ||||
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